Vayne excels against tanks and immobile champions, utilizing her true damage and invisibility for kiting and sustained damage.
She is weak against top lane bruisers and dive champions, so pick her cautiously as a counter; currently, she is an off-meta pick in bot lane.
She synergizes well with peel supports like Lulu or Thresh, but be wary of slow lane clear compositions as they can prolong and complicate the game.
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