In patch 14.21, Jungle Karthus was played in 32,961 games in Emerald + tier, with a 50.38% win rate and a 2.78% pick rate. Current rank of the champion is 3 Tier, and the most popular core items include , , and The most popular runes include (, , , ) for primary path and (, ) for secondary path.
Karthus strong against , , and but weak against Karthus include , , and .
Karthus performs strongest at 0-25 minutes with a 51.41% win rate and weakest at 40+ minutes with a 49.07% win rate.