In patch 14.22, Jungle Karthus was played in 23,028 games in Emerald + tier, with a 50.75% win rate and a 2.66% pick rate. Current rank of the champion is 3 Tier, and the most popular core items include , , and The most popular runes include (, , , ) for primary path and (, ) for secondary path.
Karthus strong against , , and but weak against Karthus include , , and .
Karthus performs strongest at 0-25 minutes with a 52.01% win rate and weakest at 35-40 minutes with a 48.56% win rate.