In patch 14.22, Jungle Karthus was played in 2,759 games in Emerald + tier, with a 50.49% win rate and a 3.14% pick rate. Current rank of the champion is 3 Tier, and the most popular core items include , , and The most popular runes include (, , , ) for primary path and (, ) for secondary path.
Karthus strong against , , and but weak against Karthus include , , and .
Karthus performs strongest at 25-30 minutes with a 54.66% win rate and weakest at 35-40 minutes with a 42.94% win rate.